endometrial carcinosarcoma pathology pathology in outline format with mouse over histology previews. Micro. Endometrial carcinoma is divided into numerous histologic categories based on cell type ( Table 1 ). A subtle pattern of myoinvasion in low grade endometrial endometrioid carcinomas, microcystic, elongated and fragmented (MELF) should be searched for in the absence of frank invasion. At low power, microcystic tumor glands lie separated by muscle from non-invasive carcinoma in edematous stroma. Kurman, RJ. Left ovary and fallopian tube, salpingo-oophorectomy: Endometrioid adenocarcinoma, FIGO grade 1 (see synoptic report), Ovarian surface: not involved by carcinoma, Fallopian tube: not involved by carcinoma, Additional findings: background endometriotic cyst, Presence of other patterns throughout the tumor, Squamous differentiation in endometroid carcinoma, Nuclear grooves in adult granulosa cell tumor, Heterologous elements of Sertoli-Leydig cell tumor (if present), Presence of squamous differentiation in endometrioid carcinoma, Architecture: solid, papillary, labyrinthine, glandular, High mitotic activity (> 12 mitoses per 10 high power fields), Metastatic endometrial endometrioid adenocarcinoma is usually high grade (FIGO grade 3), No endometriosis / adenofibroma background, Papillary, tubular and solid architectural patterns, Immunostains are not contributory in differential diagnosis, Low grade tumor and nuclear beta catenin expression. In such cases, use of immunohistochemical markers and identification of specific nonrandom chromosomal rearrangements may … resembling sex High grade nuclei upgrades cancer by one. Doctors class carcinosarcomas as a type of endometrial cancer as they have similar risk factors and behave in a similar way. CEA was more common in endocervi-cal adenocarcinomas (62%), than in endometrial ade-nocarcinomas (27%). At any rate, whereas 5 (20.8%) of the 24 patients in our study died of disease at a mean follow-up time of 54 months, only 2 (10.5%) of 19 patients with carcinoma which clearly had a myometrial villoglandular component in the study by Zaino et al. Obstet Gynecol. Ayhan A, Taskiran C, Yuce K, Kucukali T (January 2003). The degree of histologic differentiation of endometrial cancer has long been accepted as a sensitive indicator of prognosis. Incidence -Endometrial carcinoma is the most common gynecologic malignancy. In the United States, there is a greater incidence among patients of European descent compared those of African American descent. that are of practical relevance in daily surgical pathology practice. Endometrial carcinoma in situ in postmenopausal women. Endometrioid endometrial carcinoma, abbreviated EEC, is the most common type of endometrial carcinoma. Squamous morules in endometrioid endometrial carcinoma - not associated with. Cancer. Focally, a desmoplastic stroma is also identified. Introduction. Contents. Endometrial carcinoma, also endometrial adenocarcinoma, is a common gynecologic malingnancy that often arises from endometrial hyperplasia.The incidence of endometrial carcinoma is increasing, as the proportion of obese individuals is increasing.. An introduction to the endometrium is … They generally treat them as a type 2 endometrial cancer. Percentage of surgical pathology reports with a pathological diagnosis of endometrial carcinoma that include a statement on microsatellite instability (MSI) and/or mismatch … Preliminary grade based on gland formation:[9][10][11][12]. Endometrial carcinoma is the most common gynecologic malignancy in developed countries [ 1 ]. Dawagne MP, Silverberg SG . A total of 124 endometrial carcinoma cases (24 grade 1 endometrioid, 60 grade 3 endometrioid, 40 serous) were retrieved from pathology archives. This single-institution study of 23 uterine MLCas characterizes the behavior of such a neoplasm. Introduction Endometrial carcinoma is generally divided into two settings, type I and the type II, based primitively on whetherornotitisestrogenic(Fig. The behavior of endometrial hyperplasia. Karamurzin, Y.; Soslow, RA. 1992 Oct. 80(4):655-9. . There is molecular heterogeneity. Subtyping endometrial cancer 3. delicate cores and tufts. Tadrous says: high grade nuclei = increased size, irregular large nucleoli, irregular chromatin pattern (clumped, coarse). On histologic examination, PPE ranges from simple papillae with fibrovascular cores, often involving the surface of endometrial polyps, to complex int … © Copyright PathologyOutlines.com, Inc. Click, Contributed by Sakinah A Thiryayi, M.D. Endometrial carcinoma is generally divided into two settings, type I and the type II, based primitively on whetherornotitisestrogenic(Fig . GENERAL HISTOPATHOLOGIC FEATURES. Endometrial Carcinoma Pathology Outlines Uterus Causes Cancer Symptoms effect of suture materials on healing skin wounds. "Evaluation of criteria for distinguishing atypical endometrial hyperplasia from well-differentiated carcinoma.". Endometrial Carcinoma High Quality Pathology Images of Gynecologic: Uterus of Endometrial Carcinoma. However, we cannot answer medical or research questions or give advice. Recent work predominantly carried out in tubo-ovarian high-grade serous carcinoma has revealed 4 main patterns of p53 staining (normal/wild-type, complete absence, overexpression, and cytoplasmic); the … 2.1 Images; 3 Sign out; 4 See also; 5 References; General. Outline Pathology of the Vagina and Cervix The Vagina The Vaginal Cuff Rectouterine Recess Cervix Pathology of the Uterus Normal Variations of the Uterus Leiomyomas Uterine Calcifications Adenomyosis Arteriovenous Malformations Uterine Leiomyosarcoma Pathology of the Endometrium Sonohysterography Endometrial Hyperplasia Endometrial Polyps Endometritis Synechiae Endometrial Carcinoma … The sections show endometrium with complex, fused and cribriform glands with scant intervening stroma over a region measuring greater than 2.1 millimetres. Eur J Surg Oncol 2016; 42:1367. Histologic differentiation. papillary, solid with slit-like spaces. Endometrial Cancer Prognostic features: Age Depth of invasion Stage Peritoneal cytology Race Vascular invasion Grade FIGO Staging - Corpus Cancer IA Tumor limited to endometrium IB Invasion to <1/2 of myometrium IC Invasion to > 1/2 myometrium II Involvement of corpus and cervix III Extension outside of uterus, but not outside of true pelvis We investigated the possibility of distinguishing between primary endometrial and endocervical adenocarcinomas by using a panel of immunohistochemical stains, which included vimentin (VIM), carcinoembryonic antigen (CEA), epithelial membrane antigen (EMA), … Endometrial carcinoma. Uterine carcinosarcoma. The uterine endometrial polyp (EMP) has a potential risk of developing malignant tumors especially in postmenopausal women. Lax, SF. Related content is discussed in separate topics, including: Histopathology and pathogenesis – (See "Endometrial cancer: Pathology and classification".) We detected 106 consecutive patients with primary endometrial carcinoma (type I/ endometrioid, n=84; type II/ nonendometrioid, n=20; rare subtypes, n=2) who were treated at our institution between 1999 and 2009. "Unusual epithelial and stromal changes in myoinvasive endometrioid adenocarcinoma: a study of their frequency, associated diagnostic problems, and prognostic significance". Benha University Hospital, Egypt Email:elnashar53@hotmail.com 2. The purpose of this study was to evaluate the association between p53 and PAX 8 expression and the clinical value of PAX 8 in endometrial carcinoma. Accuracy of preoperative endometrial sampling diagnosis for predicting the final pathology grading in uterine endometrioid carcinoma. Eosinophilic tumor cells or squamous cells can often be seen within the lumens. doi: 10.1097/PGP.0000000000000488. The ovaries and tubes usually are removed incidentally to the endometrial carcinoma and therefore would be bundled under the code 88309 ( uterus with or without tubes and ovaries , neoplastic). Endometrial hyperplasia. (Jun 1982). Only 5% of patients are younger than 40 years. Kurman RJ, Kaminski PF, Norris HJ. Winham, WM. Endometrioid carcinoma with papillary architecture, Endometrioid adenocarcinoma, FIGO grade 1, Endometrioid adenocarcinoma, FIGO grade 2, Endometrioid adenocarcinoma, FIGO grade 3, Trabecular pattern Uterine leiomyoma. Thebackgroundendometriumin these uteri with superficial endometrial carcinoma showedcystic hyperplasia with benign polyps (fig 5). Guan H, Semaan A, Bandyopadhyay S, et al. At higher power lie microcystic glands with neutrophils, as well as elongated glands lined by flattened tumor cells. Histotype prediction was derived from a … Aims:: To investigate the frequency of microcystic, elongated and fragmented (MELF) pattern invasion in endometrial carcinoma and its association with other pathological findings. endometrial clear cell carcinoma pathology pathology in outline format with mouse over histology previews. Endometrioid endometrial carcinoma, abbreviated EEC, is the most common type of endometrial carcinoma. † There is a size cut-off for criteria 2, 3 and 4: > 2.1 mm. Click. All women were postmenopausal, 47-89 years of … The authors also noted that CEA appeared to be … From Libre Pathology. 1).1,2 Thedistinction between these two settings could be easily understood Dysfunctional uterine bleeding - other pathologies excluded. We reviewed 18 cases of mucinous adenocarcinoma of the endometrium seen at this hospital during 1969-1985. Endometrial and ovarian lesions have identical morphology (see image). CAS Article Google Scholar 35. Pathology. OUTLINE OF TALK ... between different types of high-grade endometrial carcinoma (grade 3 endometrioid, serous, clear cell, carcinosarcoma, undifferentiated) •At present, management is similar, although MAY ; Malpica, A.; Deavers, MT. -The disease predominantly affects perimenopausal and postmenopausal women, whose median age at diagnosis is 61 years. Endometrial mesonephric-like carcinomas (MLCa) are uncommon with <50 reported cases thus far. Atypical (ovoid) glands with - one of the following four: Ball of cells with an intensely eosinophilic cytoplasm -. ; Silva, EG. It has long been recognized that nonsynonymous TP53 missense mutations result in nuclear accumulation of p53 protein that can be detected as overexpression by immunohistochemistry. of Gynecological Pathology, two papers addressed this problem. Undifferentiated carcinoma (which when associated with a component of low-grade endometrioid carcinoma is termed "dedifferentiated carcinoma") is composed of sheets of monotonous, typically dyscohesive cells, which can have a rhabdoid appearance; they often exhibit limited expression of cytokeratins and epithelial membrane antigen, are usually negative for PAX8 and hormone receptors, … Visual survey of surgical pathology with 11065 high-quality images of benign and malignant neoplasms & related entities. "Endometrial squamous metaplasia. It ... - FALLOPIAN TUBES WITHOUT SIGNIFICANT PATHOLOGY. "Morules in endometrial carcinoma and benign endometrial lesions differ from squamous differentiation tissue and are not infected with human papillomavirus.". EIC has been identified in a high proportion of uteri containing serous carcinoma, but its association with other endometrial tumors is unknown. Incidence -Endometrial carcinoma is the most common gynecologic malignancy. Eight patients with EIC in the EMP, who were postmenopausal with ages ranging from 49 to 76 years (av. Role of diagnostic pathology in guiding management of endometrial cancer 2. "Architectural versus nuclear atypia-defined FIGO grade 2 endometrial endometrioid adenocarcinoma (EEC): a clinicopathologic comparison of 154 cases with clinical follow-up.". 24, 25, 26 Due to its common occurrence, this variant is also known as typical endometrial adenocarcinoma. P53 immunohistochemistry has evolved into an accurate surrogate reflecting the underlying TP53 mutation status of a tumor, and has utility in the diagnostic workup of endometrial carcinomas. "Immunohistochemical overexpression of p16 and p53 in uterine serous carcinoma and ovarian high-grade serous carcinoma.". Abnormal uterine bleeding, abbreviated AUB, is a clinical diagnosis in which the underlying cause has not been determined. Endometrial Carcinoma High Quality Pathology Images of Gynecologic: Uterus of Endometrial Carcinoma . 1 General; 2 Microscopic. Uterine yolk sac tumors have gained increased recognition in recent years. [16]. Benha University Hospital, Egypt Email:elnashar53@hotmail.com 2. Secretory adenocarcinomas of the endometrium are uncommon tumors distinct from clear cell carcinomas. Endometrial cancer incidence in the United States has been rapidly rising in recent years. In three additional cases a superficial endome-trial carcinoma (fig 5) confined to the endometriumoccurredwithin anendometrial polyp. uterine MLCas characterizes the behavior of such a neoplasm. Background. Based on gland formation & adjusted by nuclear pleomorphism. It is strongly associated with obesity. (Mar 2014). Determinants of survival of surgically staged patients with endometrial carcinoma histologically confined to the uterus: implications for therapy. Chiesa-Vottero, AG. Many endometrial adenocarcinomas, particularly those of endometrioid type, express estrogen receptors (ERs), progesterone receptors (PRs), and vimentin. Although most of this work ha… Endometrial carcinoma 1. A 48 year old woman with endometrial carcinoma underwent laparoscopic staging procedure and a right ovarian adenocarcinoma was identified. Murray SK, Young RH, Scully RE (2003). Endometrial ablation is done to treat menorrhagia and metromenorrhagia in women that are done with their childbearing. The correlation between frozen section and final pathology for histology, grade, and depth of myometrial invasion is approximately 97.5%, 88%, and 98.2%, respectively 18. ; Garg, K. (Apr 2013). (May 1995). Associated with estrogen excess (unopossed estrogen stimulation). Tissue microarrays were constructed. Causes. A short video covering the types of endometrial carcinoma, risk factors and prognosis. Tumor histology was studied in curettage and hysterectomy material; the Hospital Tumor Registry provided follow-up data. Home; About Us; Acknowledgements; Feedback; Contact Us; Site Map; High Quality Pathology Images of Benign and Malignant Neoplasms … hysterectomy for endometrial cancer grossing, Complex endometrial hyperplasia with atypia, Squamous morule with dyskeratotic cell (diagnosticpathology.org), Ductal adenocarcinoma of the prostate gland, Microcystic elongated and fragmented glands in endometrioid endometrial carcinoma, http://www.cap.org/apps/docs/committees/cancer/cancer_protocols/2011/Endometrium_11protocol.pdf, http://dictionary.reference.com/browse/dyskeratosis, http://www.pathologyoutlines.com/uterus.html#endometrialcarc, http://www.emedicine.com/med/topic2832.htm, https://librepathology.org/w/index.php?title=Endometrioid_endometrial_carcinoma&oldid=48696, Attribution-NonCommercial-ShareAlike 4.0 International, ER +ve, PR +ve, vimentin +ve, p16 -ve, CEA -ve. uterus pathology pathology in outline format with mouse over histology previews. It has been suggested that this increase is due in part to declining rates of hysterectomy for benign causes. Associated with estrogen excess (unopossed estrogen stimulation). This website is intended for pathologists and laboratory personnel but not for patients. Furthermore, high-risk disease is identified more efficiently in frozen section compared with low-risk disease 19. Grading endometrial cancer 4. Endometrial carcinoma is the most common gynecological malignancy, with peak incidence at around the 6thdecade, though 12% of cases present in premenopausal women. High prevalence of endometriosis in individuals with hysterectomy post-ablation procedure. CAS Article Google Scholar 49. These malignancies include endometrial intraepithelial carcinoma (EIC). Mariani A, Dowdy SC, … No nuclear atypia is appreciated. Management of SIL Thomas C. Wright, Jr. PAX 8 and p53 expression were assessed using immunohistochemistry from paraffin-embedded tissue blocks. Serous carcinoma (SC) represents ~10% of endometrial carcinomas, but is responsible for almost 40% of cancer deaths. (Jan 2002). Key words: endometrial carcinomas, genetic analysis, immunohistochemistry, uterine corpus. ; Nucci, MR.; Quick, CM. It has features of both endometrial cancer and sarcoma when looked at under a microscope. Synchronous endometrial and ovarian cancers (SEOs) have been reported in 5% to 10% of endometrial or ovarian cancers ( 1, 2).When organ confined and low grade, SEOs behave as if they were two independent primary tumors rather than an advanced-stage carcinoma of either ovary or endometrium. Carcinosarcoma is a rare type of womb cancer. Copenhaver EH . Aggressive behaviour - high probability of disseminated disease. OUTLINE OF TALK •General points (Murali Varma covered) •Benign endometrial pathology •Premalignant and malignant endometrial pathology (biopsies and resections) •MANY OF TIPS ARE PERSONAL AND EVERYONE MAY NOT AGREE . Type I (80%) arises in the setting of unopposed hyperestrogenism and endometrial hyperplasia. 56(2):403-12. . Measure Description . Pathology - Journal of the RCPA: August 2009 - Volume 41 - Issue 5 - p 454–459. An overview of endometrial carcinoma can be found separately (see "Overview of endometrial carcinoma"). Castrillon et al (1) studied 30 endometrial adenocarcinomas and 29 endocervical adenocarcino-mas, and included tumors with overlapping morpho-logic features. LDL low density lipoprotein. Uterine MLCas (2004-present) had review of histologic features, immunohistochemical results, molecular profile, and clinical information (stage, treatment, follow-up). ; Mazur, MT. Outline of Syllabus 1. 30100 Telegraph Road, Suite 408, Bingham Farms, Michigan 48025 (USA). We reviewed nine cases that included the original endometrial curettings and the specimens of uteri with both adnexa [total abdominal hysterectomy-bilateral … Endometrial carcinoma is divided into numerous histologic categories based on cell type ().The most common cell type, endometrioid, accounts for 75% to 80% of cases. (Jul 2007). No nuclear … With increased refinement of immunohistochemistry, we, and others, observed other abnormal p53 expression patterns that correlate with the presence of a TP53 mutation. Advertisement. Recent work predominantly carried out in tubo-ovarian high-grade serous carcinoma has revealed 4 main pattern … Interpretation of P53 Immunohistochemistry in Endometrial Carcinomas: Toward Increased Reproducibility Int J Gynecol Pathol. died of disease (mean follow-up time is unknown to us). ENDOMETRIAL PATHOLOGY REPORTING: WHAT REALLY MATTERS- WHEN AND WHY W Glenn McCluggage Belfast United Kingdom. psammoma bodies. Thermal injury - delivered via balloon. Am J Surg Pathol 1995; 19: 417–432. Endometrial carcinoma is divided into two subtypes - type I and type II. Abstract. "The prognostic value of nuclear grading and the revised FIGO grading of endometrial adenocarcinoma". Clear cell carcinomas of the endometrium can be associated with mutations in POLE (in which case they have a very favorable prognosis), mismatch repair deficiency (which may be a result of Lynch syndrome), mutations in TP53 (poor prognosis) or none of the above. Eur J Surg Oncol 2016; 42:1367. Follow us: 11065 Images : Last Website Update : March 2, 2021. Focused Endometrial Carcinoma with stained slides of pathology. Endometrial carcinoma 1. Only 5% of patients are younger than 40 years. An unusual response to progestin therapy of hyperplasia.". Miranda, MC. Foam cells in endometrial carcinoma: a clinicopathologic study. Endometrial stromal sarcoma. doi: 10.1080/00313020903041135. Focally, a desmoplastic stroma is also identified. of fluid Endometrial Carcinoma Pathology Outlines ovarian cancer surgery complications symptoms fast heartbeat Uterus Causes Cancer Symptoms collected behind the fetal neck in an area called the nuchal fold is measured. 2019 Jan;38 Suppl 1(Iss 1 Suppl 1):S123-S131. A long-term study of "untreated" hyperplasia in 170 patients. and Gulisa Turashvili, M.D., Ph.D. (Case #500), Mod Pathol 2020 Dec 16 [Epub ahead of print], Metastatic endometrial endometrioid adenocarcinoma, Ovarian carcinoma resembling endometrioid adenocarcinoma of the endometrium, Usually low grade and diagnosed at early stages, May be associated with endometriosis and adenofibroma, Seromucinous carcinoma is included as a subtype of endometrioid ovarian carcinoma in the 2020 WHO blue book for female genital tumors, Associated with endometriosis / endometriotic cyst (15%), endometrioid adenofibroma, synchronous endometrial endometrioid adenocarcinoma or endometrial hyperplasia (15 - 30%) (, Risk factors: endometriosis, hormone replacement therapy, first degree family history of breast carcinoma (, May occur in the setting of Lynch syndrome (, Most common molecular alterations: WNT / beta catenin signaling pathway (, Most common symptoms are abdominal distention and pain, Background endometriosis is not associated with survival (, Most common appearance is a cystic lesion (, Stage is the most important prognostic factor, Survival rates: > 95% for stage IA and IB and 51% for stage III and IV (, Most tumors are confined to the ovary at diagnosis, Synchronous endometrioid carcinomas of the endometrium and ovaries are often clonally related but typically have indolent clinical behavior (, 39 year old woman with Cowden syndrome incidentally detected from a metachronous ovarian endometrioid carcinoma (, 41 year old woman with mixed adenocarcinoma and yolk sac tumor (, 45 year old woman with endometrial endometrioid and synchronous bilateral endometrioid ovarian cancer (, 52 year old woman with ovarian mass on computed tomography imaging and a raised CA-125 (, 65 year old postmenopausal woman with ovarian endometrioid carcinoma presenting as an abdominal wall abscess (, Adjuvant chemotherapy is associated with survival benefit for patients with inadequately staged and grade 2 stage I cancers (, Patients with advanced stage disease (FIGO III and IV) might benefit from platinum based chemotherapy (, Cystic with solid component and areas of hemorrhage, With or without polypoid nodule in endometriotic cyst, Mean tumor size: 11 cm (range: 3 - 22 cm), Depending on histologic grade, a combination of glandular and solid areas may be seen, Differential diagnosis depends on histologic grade but includes metastatic carcinoma, well differentiated Sertoli-Leydig cell tumor and serous carcinoma (, Most common morphologic pattern is confluent (back to back) glands, Stromal invasion is usually by expansion; rarely, destructive stromal invasion can be observed, Squamous metaplasia (morules or keratin pearls), cytoplasmic mucin, intracytoplasmic vacuoles, oncocytic changes, clear cell changes and cilia and sex cord-like elements (sertoliform) can be observed; none of these morphologic features affect the histologic grade (, Histologic grading: same as for endometrial endometrioid adenocarcinoma, FIGO grade 1: less than 5% solid component, FIGO grade 3: more than 50% solid component, Endometriosis or adenofibroma may be present in the background, Might be associated with serous, undifferentiated carcinoma and yolk sac tumor (mixed carcinoma) (. A short video covering the types of endometrial carcinoma, risk factors and prognosis. Atrophy. Which of the following is associated with favorable disease outcome in patients with ovarian endometrioid carcinoma? It is also known as endometrioid endometrial adenocarcinoma. Aims:: To investigate the frequency of microcystic, elongated and fragmented (MELF) pattern invasion in endometrial carcinoma and its association with other pathological findings. Pathology of the EndometriumPathology of the Endometrium Thomas C. Wright Columbia University, New York, NY Changes in the Uterus Th h t lifThoughout life there are marked changes in the size of the uterus. The majority are adenocarcinoma. "Histologic evaluation of prophylactic hysterectomy and oophorectomy in Lynch syndrome.". of Gynecological Pathology, two papers addressed this problem. 24,25,26 Due to its common occurrence, this variant is also known as typical endometrial adenocarcinoma. hobnailing. -The disease predominantly affects perimenopausal and postmenopausal women, whose median age at diagnosis is 61 years. high grade nuclei. ; Lin, D.; Stone, PJ. What clinical manifestations have most commonly been associated with functioning stroma in ovarian tumors? Endometrial intraepithelial carcinoma (EIC) is a recently described lesion characterized by replacement of endometrial surface epithelium or glands by malignant cells resembling high-grade invasive endometrial carcinoma. Endometrial intraepithelial carcinoma (EIC) is a recently described lesion characterized by replacement of endometrial surface epithelium or glands by malignant cells resembling high-grade invasive endometrial carcinoma. Endometrial Carcinoma Testing for MMR, MSI, or Both. Staging endometrial cancer (including lymphovascular invasion (LVI)) 5. CEA was more common in endocervi-cal adenocarcinomas (62%), than in endometrial ade-nocarcinomas (27%). We welcome suggestions or questions about using the website. Cotran, Ramzi S.; Kumar, Vinay; Fausto, Nelson; Nelso Fausto; Robbins, Stanley L.; Abbas, Abul K. (2005). Prognosis and reproducibility of new and existing binary grading systems for endometrial carcinoma compared to FIGO grading in hysterectomy … "[Dualistic model of molecular pathogenesis in endometrial carcinoma].". Buy; Metrics Abstract. endometrial clear cell carcinoma pathology pathology in outline format with mouse over histology previews. This is in the form of diffuse strong nuclear positivity involving at least 80% of the tumor cells but usually almost 100%. The sections show endometrium with complex, fused and cribriform glands with scant intervening stroma over a region measuring greater than 2.1 millimetres. endometrial carcinoma; in both, the tumour showed extensive myometrial infiltration. Authors Martin Köbel 1 , Brigitte M Ronnett, Naveena Singh, Robert … ; Norris, HJ. Castrillon et al (1) studied 30 endometrial adenocarcinomas and 29 endocervical adenocarcino-mas, and included tumors with overlapping morpho-logic features. The foamy histiocytes in the stroma and lack of desmoplasia slightly favour an endometrial origin; however, the lesion would be best classified with an excisional specimen and in conjunction with the clinical impression.
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