Though uterine cancer's cause is unknown, there are many factors that will put a woman at risk, including being over age 50, having endometrial hyperplasia, using hormone replacement therapy, obesity, using tamoxifen, being Caucasian, and/or having colorectal cancer. Reproductive factors and postmenopausal hormone use in relation to endometrial cancer risk in the Nurses' Health Study cohort 1976-2004. La Vecchia C, Franceschi S, Decarli A, et al. Risk factors for endometrial cancer at different ages. Some women get it without being at high risk. The following factors may raise a woman’s risk of developing uterine cancer: Age. Guidelines were established to enable surgeons to minimize the risks of subsequent uterine cancer in women with abnormal uterine bleeding that is unresponsive to … Have obesity (an abnormally high, unhealthy amount of body fat). Endometrial Cancer Risk Factors, Hormone Receptors, and Mortality Prediction Cancer Epidemiol Biomarkers Prev. Being overweight or obese greatly increases a woman’s chance of developing endometrial cancer. The cells in fatty tissue also make estrogen, which helps explain why obesity (50 pounds or more overweight) is the biggest risk factor for developing this cancer. The average age at diagnosis is 60. There is no way to predict whether an individual woman will get endometrial cancer, and there is no way to screen for this disease. 2017 May;26(5):727-735. doi: 10.1158/1055-9965.EPI-16-0821. Risk Factors. Women's Wellness: Obesity increases endometrial cancer risk Sept. 17, 2020, 03:15 p.m. CDT; Women's Wellness: Researchers look at post menopause as key factor in endometrial cancer Jan. 30, 2020, 10:30 p.m. CDT; Mayo Clinic researchers look at post menopause as key factor in endometrial cancer Dec. 16, 2019, 01:30 p.m. CDT Possessing one of these risk factors does not mean that a woman will develop endometrial cancer but rather that her risk of developing endometrial cancer is higher than that of another woman without the risk factor. Uterine cancer most often occurs in women over 50. A small number of endometrial cancers are type 2 endometrial cancer. +65 6254 2878 (Thomson) When a woman has high circulating levels of estrogen and low levels of progesterone over long periods of time, the risk for uterine (endometrial) cancer rises. Other risk factors include age, family history, a diagnosis of polycystic ovary syndrome and prior use of the breast cancer … Epub 2017 Jan 4. Knowing your risk factors and talking about them with your doctor may help you make more informed lifestyle and health care choices that may help you minimize your cancer risk. Endometrial cancer starts in the lining of the uterus — the endometrium. Endometrial cancer prevention strategies include avoiding risk factors when possible and increasing protective factors that may help prevent cancer. However, several factors may increase the chance that you will get uterine cancer, including if you— Are older than 50. J Natl Cancer Inst 1984; 73:667. Learn more about known risk and protective factors and approaches to prevent endometrial cancer in this expert-reviewed summary. The exact cause of endometrial carcinoma remains unknown, although several risk factors have been identified. (See Endometrial Cancer Risk Factors for more on this.) Endometrial cancer is a life-threatening disease that is linked to several causes. Karageorgi S, Hankinson SE, Kraft P, De Vivo I. There is no way to know for sure if you will get uterine cancer. They sometimes develop from atypical hyperplasia, an abnormal overgrowth of cells in the endometrium. It is possible to develop endometrial cancer without being at high risk, and it is possible to be at high risk and not develop it. Type 2 cancers are more likely to grow and spread outside the uterus, they have a poorer outlook (than type 1 cancers). Check out these 10 predisposing factors that can put you at risk. A focused list of high-risk factors for endometrial carcinoma was developed on the basis of the data collected.
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